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Article Title |
Author(s) |
Type (Status) |
Available Online |
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TACE treatment in hepatocellular carcinoma: what should we do now?
DOI: 10.1016/j.jhep.2011.12.022
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Fabio Farinati,
Anna Giacomin,
Veronica Vanin,
Edoardo Giannini,
Franco Trevisani
et al.
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Correspondence
(In Press Accepted Manuscript)
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27 January 2012 |
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Genetic testing for hepatocellular carcinoma: an ambitious goal still to achieve
DOI: 10.1016/j.jhep.2011.12.023
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Enrico Galmozzi,
Massimo Colombo
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Discussion
(In Press Accepted Manuscript)
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27 January 2012 |
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Liver transplantation for severe alcoholic hepatitis saves lives
DOI: 10.1016/j.jhep.2012.01.003
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Andrew K. Burroughs
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Discussion
(In Press Accepted Manuscript)
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27 January 2012 |
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At the cancer steering wheel: Defining key genomic drivers of liver cancer with next generation sequencing
DOI: 10.1016/j.jhep.2011.12.024
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Anuradha Budhu,
Xin Wei Wang
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Discussion
(In Press Accepted Manuscript)
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27 January 2012 |
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Post-liver transplantantion graft biopsies should not be used to assess the IL28B donor genotype in HCV recipients
DOI: 10.1016/j.jhep.2011.11.025
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Maria Francesca Donato,
Enrico Galmozzi,
Cristina Rigamonti,
Alessio Aghemo
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Correspondence
(In Press Accepted Manuscript)
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27 January 2012 |
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Molecular epidemiology in HCV-related hepatocellular carcinoma: first steps
DOI: 10.1016/j.jhep.2012.01.002
Abstract: Chronic viral hepatitis is the most important risk factor for progression to hepatocellular carcinoma (HCC). To identify genetic risk factors for progression to HCC in individuals with chron...
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Augusto Villanueva,
Xavier Forns,
Josep M. Llovet
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Discussion
(In Press Accepted Manuscript)
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25 January 2012 |
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The Option of HBIG-Free Prophylaxis Against Recurrent HBV
DOI: 10.1016/j.jhep.2011.08.026
Abstract: Since the early 1990’s, hepatitis B immune globulin (HBIG) has been central to the prevention of hepatitis B virus (HBV) recurrence after liver transplantation. When used in combination with...
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Alyson N. Fox,
Norah A. Terrault
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Discussion
(In Press Accepted Manuscript)
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23 January 2012 |
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Prevention of Acute Kidney Injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression
DOI: 10.1016/j.jhep.2011.11.024
Abstract: Background and aims: Superimposed infection and/or inflammation precipitates renal failure in cirrhosis. This study aimed to test the hypothesis that increased gut bacterial translocation in...
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Naina Shah,
Dipok Dhar,
Fatma Mohammed,
Abeba Habtesion,
Nathan A. Davies,
Maria Jover-Cobos,
Jane Macnaughtan,
Vikram Sharma,
Steven OldeDamink,
Rajeshwar P. Mookerjee,
Rajiv Jalan
et al.
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Full-length article
(In Press Accepted Manuscript)
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18 January 2012 |
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A novel biliary stent loaded with 125I seeds in patients with malignant biliary obstruction: preliminary results versus a conventional biliary stent
DOI: 10.1016/j.jhep.2011.12.018
Abstract: Background & aims: Stenting is a palliative therapy method for relieving malignant biliary obstruction. The aim was to evaluate the safety and effectiveness of a irradiation stent when c...
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Hai-Dong Zhu,
Jin-He Guo,
Guang-Yu Zhu,
Shi-Cheng He,
Wen Fang,
Gang Deng,
Yong-Lin Qin,
Guo-Zhao Li,
Douglas M. Coldwell,
Gao-Jun Teng
et al.
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Full-length article
(In Press Accepted Manuscript)
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18 January 2012 |
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A Randomized Trial of 48 versus 24 Weeks of Combination Pegylated Interferon and Ribavirin Therapy in Genotype 6 Chronic Hepatitis C
DOI: 10.1016/j.jhep.2011.12.020
Abstract: Background and Aims: Genotype 6 chronic hepatitis C is encountered predominantly in Southeast Asia and data on optimal treatment strategy is limited. This study was aimed to assess the rate ...
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Pham Thi Thu Thuy,
Chalermrat Bunchorntavakul,
Ho Tan Dat,
K. Rajender Reddy
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Full-length article
(In Press Accepted Manuscript)
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18 January 2012 |
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Efficacy of non-selective β-blockers as adjunct to endoscopic prophylactic treatment for gastric variceal bleeding: A randomized controlled trial
DOI: 10.1016/j.jhep.2011.12.021
Abstract: Background and aims: Gastric variceal obturation (GVO) therapy is the current treatment of choice for gastric variceal bleeding (GVB). However, the efficacy of non-selective ß-blockers (NSBB...
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Hung-Hsu Hung,
Chen-Jung Chang,
Ming-Chih Hou,
Wei-Chih Liao,
Che-Chang Chan,
Hui-Chun Huang,
Han-Chieh Lin,
Fa-Yauh Lee,
Shou-Dong Lee
et al.
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Full-length article
(In Press Accepted Manuscript)
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18 January 2012 |
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Molecular forms of HMGB1 and Keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
DOI: 10.1016/j.jhep.2011.12.019
Abstract: Background & Aims: Full length keratin-18 (FL-K18) and High Mobility Group Box-1 (HMGB1) represent circulating indicators of necrosis during acetaminophen (APAP) hepatotoxicity in vivo. ...
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Daniel J. Antoine,
Rosalind E. Jenkins,
James W. Dear,
Dominic P. Williams,
Mitchell R. McGill,
Matthew R. Sharpe,
Darren G. Craig,
Kenneth J. Simpson,
Hartmut Jaeschke,
B. Kevin Park
et al.
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Full-length article
(In Press Accepted Manuscript)
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18 January 2012 |
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Histamine regulation of biliary proliferation
DOI: 10.1016/j.jhep.2011.09.023
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Heather Francis,
Fanyin Meng,
Gianfranco Alpini
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Discussion
(In Press Accepted Manuscript)
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16 January 2012 |
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High intrahepatic HHV-6 virus loads but neither CMV nor EBV are associated with decreased graft survival after diagnosis of graft hepatitis
DOI: 10.1016/j.jhep.2011.12.017
Background & Aims: In liver transplant recipients with graft hepatitis, the relevance of herpesviruses is not well defined. Methods: Viral loads of CMV, EBV, and HHV-6 were determined in blood and...
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Sven Pischke,
Juliane Gösling,
Ilka Engelmann,
Jerome Schlue,
Benno Wölk,
Elmar Jäckel,
Christoph Meyer-Heithuis,
Ulrich Lehmann,
Christian P. Strassburg,
Hannelore Barg-Hock,
Thomas Becker,
Michael P. Manns,
Thomas Schulz,
Heiner Wedemeyer,
Albert Heim
et al.
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Vandetanib in patients with inoperable hepatocellular carcinoma: a phase II, randomized, double-blind, placebo-controlled study
DOI: 10.1016/j.jhep.2011.12.013
Abstract: Background and Aims: Inhibitors of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) have shown anti-tumor activities in advanced hepatocellular...
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Chiun Hsu,
Tsai-Sheng Yang,
Teh-Ia Huo,
Ruey-Kuen Hsieh,
Chih-Wei Yu,
Wei-Shou Hwang,
Tsai-Yuan Hsieh,
Wen-Tsung Huang,
Yee Chao,
Robin Meng,
Ann-Lii Cheng
et al.
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Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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4-phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration
DOI: 10.1016/j.jhep.2011.11.021
Abstract: Background& aims: Multidrug resistance-associated protein 2 (in humans, MRP2; in rodents, Mrp2) mediates biliary excretion of bilirubin glucuronides. Therefore, upregulation of MRP2/Mrp2...
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Hisamitsu Hayashi,
Tadahaya Mizuno,
Reiko Horikawa,
Hironori Nagasaka,
Takashi Yabuki,
Hajime Takikawa,
Yuichi Sugiyama
et al.
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Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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Validation of A Stopping Rule at Week 12 Using HBsAg and HBV DNA for HBeAg-Negative Patients Treated with Peginterferon Alfa-2a
DOI: 10.1016/j.jhep.2011.12.007
Abstract: Background &Aims: It was recently demonstrated that none of the hepatitis B e antigen (HBeAg-)negative patients without any serum hepatitis B surface antigen (HBsAg) decline and with <...
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Vincent Rijckborst,
Bettina E. Hansen,
Peter Ferenci,
Maurizia R. Brunetto,
Fehmi Tabak,
Yilmaz Cakaloglu,
A. Galeota Lanza,
Vincenzo Messina,
Claudio Iannacone,
Benedetta Massetto,
Loredana Regep,
Massimo Colombo,
Harry L.A. Janssen,
Pietro Lampertico
et al.
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Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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Cost-effectiveness of semiannual surveillance for hepatocellular carcinoma in cirrhotic patients of the Italian Liver Cancer population
DOI: 10.1016/j.jhep.2011.11.022
Abstract: Background & aims: It was recently shown that semiannual surveillance for hepatocellular carcinoma (HCC) in cirrhotic patients provides a prognostic advantage over the annual program; ho...
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Alessandro Cucchetti,
Franco Trevisani,
Matteo Cescon,
Giorgio Ercolani,
Fabio Farinati,
Paolo Del Poggio,
Gianludovico Rapaccini,
Maria Anna Di Nolfo,
Luisa Benvegnù,
Marco Zoli,
Franco Borzio,
Edoardo Giovanni Giannini,
Eugenio Caturelli,
Maria Chiaramonte,
Antonio Daniele Pinna
et al.
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Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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PPARα Activation Improves Endothelial Dysfunction And Reduces Fibrosis And Portal Pressure In Cirrhotic Rats
DOI: 10.1016/j.jhep.2011.12.008
Abstract: Background & aims: Peroxisome proliferator-activated receptor α (PPARα) is a transcription factor activated by ligands that regulates genes related to vascular tone, oxidative stress and...
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Aina Rodríguez-Vilarrupla,
Bàrbara Laviña,
Héctor García-Calderó,
Lucia Russo,
Eugenio Rosado,
Núria Roglans,
Jaume Bosch,
Joan Carles García-Pagán
et al.
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Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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Renal failure and hyponatremia in patients with cirrhosis and skin and soft tissue infection. A retrospective study
DOI: 10.1016/j.jhep.2011.11.023
Background & Aims: Skin and soft tissue infection in cirrhosis is considered a non-severe infection, but specific information is lacking. This study aimed at assessing the characteristics, occurre...
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Gustavo Pereira,
Mónica Guevara,
Claudia Fagundes,
Elsa Solá,
Ezequiel Rodríguez,
Javier Fernández,
Marco Pavesi,
Vicente Arroyo,
Pere Ginès
et al.
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Full-length article
(In Press Uncorrected Proof)
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16 January 2012 |
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Relationship between baseline hepatic status and outcome, and effect of sorafenib on liver function: SHARP trial subanalyses
DOI: 10.1016/j.jhep.2011.12.009
Abstract: Background & aims: Hepatic markers are utilized in many classification systems of patients with hepatocellular carcinoma and, by measuring organ damage and tumor stage, can influence tre...
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Jean-Luc Raoul,
Jordi Bruix,
Tim F. Greten,
Morris Sherman,
Vincenzo Mazzaferro,
Philip Hilgard,
Hans Scherubl,
Max E. Scheulen,
Georgios Germanidis,
Sophie Dominguez,
Sergio Ricci,
Andrea Nadel,
Marius Moscovici,
Dimitris Voliotis,
Josep M. Llovet
et al.
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Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: a systematic review
DOI: 10.1016/j.jhep.2011.10.025
Abstract: Objective: Studies on the epidemiology of primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) show variable outcome. We aimed to systematically review the incidence and ...
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Kirsten Boonstra,
Ulrich Beuers,
Cyriel Y. Ponsioen
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Review article
(In Press Accepted Manuscript)
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16 January 2012 |
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Assessment of pathology reports on hilar cholangiocarcinoma: The results of a nationwide, multicenter survey performed by the AFC-HC-2009 study group
DOI: 10.1016/j.jhep.2011.12.010
Background & Aims: To assess the accuracy of pathology reports in patients operated on for hilar cholangiocarcinoma. Methods: Pathology reports for 263 patients operated on in 22 tertiary hepatobi...
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Denis Chatelain,
Olivier Farges,
David Fuks,
Nathalie Trouillet,
François René Pruvot,
Jean-Marc Regimbeau
et al.
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Predictors for Incidence and Remission of NAFLD in the General Population During a Seven-Year Prospective Follow-Up
DOI: 10.1016/j.jhep.2011.12.011
Abstract: Background & aims: Data on the incidence and remission rates of Non-alcoholic fatty liver disease (NAFLD) as well as predictive factors are scant. This study aims to evaluate NAFLD’s epi...
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Shira Zelber-Sagi,
Roni Lotan,
Amir Shlomai,
Muriel Webb,
Gil Harrari,
Assaf Buch,
Dorit Nitzan-Kaluski,
Zamir Halpern,
Ran Oren
et al.
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Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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The impact of organ dysfunction in cirrhosis: Survival at a cost?
DOI: 10.1016/j.jhep.2011.12.014
Background & Aims: The incidence of cirrhosis and subsequent development of organ dysfunction (OD) requiring intensive care unit (ICU) support is rising. Historically, critically ill cirrhotics ar...
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Debbie Lindsay Shawcross,
Mark J. Austin,
Robin Daniel Abeles,
Mark J.W. McPhail,
Andrew D. Yeoman,
Nicholas J. Taylor,
Andrew J. Portal,
Khaleel Jamil,
Georg Auzinger,
Elizabeth Sizer,
William Bernal,
Julia A. Wendon
et al.
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Full-length article
(In Press Uncorrected Proof)
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16 January 2012 |
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Development Of The Bile Ducts: Essentials For The Clinical Hepatologist
DOI: 10.1016/j.jhep.2011.09.022
Abstract: Several cholangiopathies result from a perturbation of developmental processes. Most of these cholangiopathies are characterised by the persistence of biliary structures with foetal configur...
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Mario Strazzabosco,
Luca Fabris
|
Review article
(In Press Accepted Manuscript)
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16 January 2012 |
|
Clinical evidence for the regression of liver fibrosis
DOI: 10.1016/j.jhep.2011.09.024
Summary: Fibrosis is a common pathological process for the majority of liver diseases which in a significant minority of patients leads to end-stage cirrhosis and/or hepatocellular carcinoma. Data eme...
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Elizabeth L. Ellis,
Derek A. Mann
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Review article
(In Press Corrected Proof)
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16 January 2012 |
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Structural and inflammatory heterogeneity in subcutaneous adipose tissue: relation with liver histopathology in morbid obesity
DOI: 10.1016/j.jhep.2011.12.015
Abstract: Background//Aim: In addition to total body fat, the regional distribution and inflammatory status of enlarged adipose tissue are strongly associated with metabolic co-morbidities of obesity....
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Joan Tordjman,
Adeline Divoux,
Edi Prifti,
Christine Poitou,
Veronique Pelloux,
Danielle Hugol,
Arnaud Basdevant,
Jean-Luc Bouillot,
Jean-Marc Chevallier,
Pierre Bedossa,
Michèle Guerre-Millo,
Karine Clement
et al.
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Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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Understanding silibinin’s modes of action against HCV using viral kinetic modeling
DOI: 10.1016/j.jhep.2011.12.012
Abstract: Background &aims: Legalon® SIL (SIL) is a chemically hydrophilized version of silibinin that has exhibited high antiviral effectiveness against hepatitis C virus (HCV). Its main mode of ...
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Jeremie Guedj,
Harel Dahari,
Ralf T. Pohl,
Peter Ferenci,
Alan S. Perelson
et al.
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Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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Tumor progression-related transmembrane protein aspartate-β-hydroxylase is a target for immunotherapy of hepatocellular carcinoma
DOI: 10.1016/j.jhep.2011.12.016
Background & Aims: Hepatocellular carcinoma (HCC) has a poor survival rate due to recurrent intrahepatic metastases and lack of effective adjuvant therapy. Aspartate-β-hydroxylase (ASPH) is an att...
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Masafumi Shimoda,
Yoshito Tomimaru,
Kevin P. Charpentier,
Howard Safran,
Rolf I. Carlson,
Jack Wands
et al.
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Full-length article
(In Press Uncorrected Proof)
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16 January 2012 |
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Alpha-fetoprotein Response Correlates with EASL Response and Survival in Solitary Hepatocellular Carcinoma Treated with Trans-arterial Therapies: A Subgroup Analysis
DOI: 10.1016/j.jhep.2011.11.020
Abstract: Background and Aims: Alpha-fetoprotein (AFP) is a universally recognized tumor marker in hepatocellular carcinoma (HCC). Its utility in assessing response to treatment remains controversial....
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Khairuddin Memon,
Laura Kulik,
Robert J. Lewandowski,
Edward Wang,
Robert K. Ryu,
Ahsun Riaz,
Paul Nikolaidis,
Frank H. Miller,
Vahid Yaghmai,
Talia Baker,
Michael Abecassis,
Al B. Benson,
Mary F. Mulcahy,
Reed A. Omary,
Riad Salem
et al.
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Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
|
Focus
DOI: 10.1016/j.jhep.2012.01.001
Almost three decades have passed since the historical NIH consensus conference which paved the road for introduction of liver transplantation (LT) into routine clinical practice worldwide. Progress in...
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Daniel Shouval
|
Discussion
(In Press Corrected Proof)
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13 January 2012 |
|
Reply to: “Deregulation of microRNAs expression occurs in stages of multistep hepatocarcinogenesis: why is it different?”
DOI: 10.1016/j.jhep.2011.12.005
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Chun-Ming Wong,
Irene Oi-Lin Ng
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Correspondence
(In Press Accepted Manuscript)
|
09 January 2012 |
|
Uncover the immune biomarkers underlying hepatitis B e antigen (HBeAg) seroconversion: A need for more translational study
DOI: 10.1016/j.jhep.2011.12.006
The Hepatitis B e antigen (HBeAg) is a non-particulate secretory protein, which is not essential for viral assembly or replication but is important for the establishment of persistent infection in viv...
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George K.K. Lau,
Fu-Sheng Wang
|
Editorial
(In Press Uncorrected Proof)
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09 January 2012 |
|
Reply to: “Interaction between IL28B and PNPLA3 genotypes in the pathogenesis of steatosis in chronic hepatitis C non genotype-3 patients”
DOI: 10.1016/j.jhep.2011.12.003
We thank Dr. Valenti et al. for raising an additional point that PNPLA3 might be associated with steatosis in the setting of HCV infection after controlling for IL28B. They demonstrate in their cohort...
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Eric Trépo,
Pierre Pradat,
Jeanette J. McCarthy,
Hans L. Tillmann
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Correspondence
(In Press Corrected Proof)
|
09 January 2012 |
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Bacterial resistance in cirrhotic patients: An emerging reality
DOI: 10.1016/j.jhep.2011.12.004
Bacterial infections are frequent and represent a relevant issue in cirrhotic patients. Susceptibility to bacterial infections is increased in cirrhotic patients for multiple reasons. These patients s...
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Manuela Merli,
Cristina Lucidi
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Editorial
(In Press Corrected Proof)
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09 January 2012 |
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Interaction between IL28B and PNPLA3 genotypes in the pathogenesis of steatosis in chronic hepatitis C non genotype-3 patients
DOI: 10.1016/j.jhep.2011.10.024
Steatosis is frequently observed in patients with chronic hepatitis C (CHC), and is associated with fibrosis progression and treatment failure . Tillmann et al. recently reported a negative associatio...
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Luca Valenti,
Alessio Aghemo,
Albert Friedrich Stättermayer
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Correspondence
(In Press Corrected Proof)
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09 January 2012 |
|
Deregulation of microRNAs expression occurs in stages of multistep hepatocarcinogenesis: why is it different?
DOI: 10.1016/j.jhep.2011.12.002
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Cai Guohong,
Liu Ya,
Yin Wen
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Correspondence
(In Press Accepted Manuscript)
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09 January 2012 |
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Identification of molecular pathways involved in oxaliplatin-associated sinusoidal dilatation
DOI: 10.1016/j.jhep.2011.10.023
Background & Aims: Oxaliplatin-based chemotherapy for colorectal liver metastases (CRLM) can result in vascular liver lesions such as sinusoidal dilatations. Physiopathology remains unclear and va...
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Julie Agostini,
Stéphane Benoist,
Marie Seman,
Catherine Julié,
Sandrine Imbeaud,
Franck Letourneur,
Nicolas Cagnard,
Philippe Rougier,
Antoine Brouquet,
Jessica Zucman-Rossi,
Pierre Laurent-Puig
et al.
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Full-length article
(In Press Corrected Proof)
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26 December 2011 |
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A dual role for hypoxia inducible factor-1α in the hepatitis C virus lifecycle and hepatoma migration
DOI: 10.1016/j.jhep.2011.11.018
Background & Aims: Hepatitis C virus (HCV) causes progressive liver disease and is a major risk factor for the development of hepatocellular carcinoma (HCC). However, the role of infection in HCC ...
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Garrick K. Wilson,
Claire L. Brimacombe,
Ian A. Rowe,
Gary M. Reynolds,
Nicola F. Fletcher,
Zania Stamataki,
Ricky H. Bhogal,
Maria L. Simões,
Margaret Ashcroft,
Simon C. Afford,
Ragai R. Mitry,
Anil Dhawan,
Christopher J. Mee,
Stefan G. Hübscher,
Peter Balfe,
Jane A. McKeating
et al.
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Full-length article
(In Press Corrected Proof)
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19 December 2011 |
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Short course adjuvant terlipressin in acute variceal bleeding: A randomized double blind dummy controlled trial
DOI: 10.1016/j.jhep.2011.11.019
Background & Aims: Terlipressin is recommended for 3–5days as adjuvant to endoscopic variceal band ligation (EVBL) in esophageal variceal bleeding (EVB). We assessed whether terlipressin can be ad...
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Zahid Azam,
Saeed Hamid,
Wasim Jafri,
Mohammad Salih,
Zaigham Abbas,
Shahab Abid,
Hasnain Shah
et al.
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Full-length article
(In Press Corrected Proof)
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19 December 2011 |
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Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways
DOI: 10.1016/j.jhep.2011.11.017
Background & Aims: miR-224 is up-regulated in human HCCs as compared to both paired peri-tumoral cirrhotic tissues and cirrhotic livers without HCC. Here, we have cloned the miR-224 regulatory reg...
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Cecilia Scisciani,
Stefania Vossio,
Francesca Guerrieri,
Valeria Schinzari,
Rossana De Iaco,
Paolo D’Onorio de Meo,
Melchiorre Cervello,
Giuseppe Montalto,
Teresa Pollicino,
Giovanni Raimondo,
Massimo Levrero,
Natalia Pediconi
et al.
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Full-length article
(In Press Corrected Proof)
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16 December 2011 |
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Snapshot liver transcriptome in hepatocellular carcinoma
DOI: 10.1016/j.jhep.2011.08.024
Hepatocellular carcinoma ranks among the most common cancers worldwide. However, besides surgery, therapeutic strategies remain limited and a detailed analysis and characterization of the tumor biolog...
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Andreas Teufel,
Jens U. Marquardt,
Frank Staib,
Peter R. Galle
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Discussion
(In Press Corrected Proof)
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14 December 2011 |
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Cell population genetics and deep sequencing: a novel approach for drivers discovery in hepatocellular carcinoma
DOI: 10.1016/j.jhep.2011.11.014
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Clara Alsinet,
Augusto Villanueva,
Josep M. Llovet
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Discussion
(In Press Accepted Manuscript)
|
14 December 2011 |
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Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines
DOI: 10.1016/j.jhep.2011.10.021
Background & Aims: Transcatheter arterial chemoembolization with lipiodol (TACE) is widely performed in patients with hepatocellular carcinoma (HCC) unsuitable for curative treatment. It has recen...
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Kenichi Takayasu,
Shigeki Arii,
Masatoshi Kudo,
Takafumi Ichida,
Osamu Matsui,
Namiki Izumi,
Yutaka Matsuyama,
Michiie Sakamoto,
Osamu Nakashima,
Yonson Ku,
Norihiro Kokudo,
Masatoshi Makuuchi
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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Renal failure and cirrhosis: A systematic review of mortality and prognosis
DOI: 10.1016/j.jhep.2011.10.016
Background & Aims: To evaluate renal failure (RF) in cirrhosis to determine and quantify its prognostic significance. Methods: Studies were identified by MEDLINE, EMBASE, Cochrane, ISI Web of Scie...
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Giuseppe Fede,
Gennaro D’Amico,
Vasiliki Arvaniti,
Emmanuel Tsochatzis,
Giacomo Germani,
Dimosthenis Georgiadis,
Alberto Morabito,
Andrew Kenneth Burroughs
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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High serum IL-21 levels after 12 weeks of antiviral therapy predict HBeAg seroconversion in chronic hepatitis B
DOI: 10.1016/j.jhep.2011.10.020
Background & Aims: Interleukin-21 (IL-21) stimulates T cell and B cell responses and plays a role in control of chronic viral infections. The role of IL-21 in chronic hepatitis B virus (HBV) infec...
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Shi-Wu Ma,
Xuan Huang,
Yong-Yin Li,
Li-Bo Tang,
Xiao-Feng Sun,
Xiao-Tao Jiang,
Yue-Xin Zhang,
Jian Sun,
Zhi-Hua Liu,
William G.H. Abbott,
Yu-Hong Dong,
Nikolai V. Naoumov,
Jin-Lin Hou
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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13C-Aminopyrine breath test accurately predicts long-term outcome of chronic hepatitis C
DOI: 10.1016/j.jhep.2011.10.015
Background & Aims: Although numerous non-invasive tests are currently available to explore liver function and disease activity in patients with HCV-related chronic diseases, none of these indicate...
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Alba Rocco,
Germana de Nucci,
Giovanna Valente,
Debora Compare,
Agesilao D’Arienzo,
Lucia Cimino,
Francesco Perri,
Gerardo Nardone
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis
DOI: 10.1016/j.jhep.2011.09.021
Summary: Liver fibrosis is an outcome of chronic liver injury of any etiology. It is manifested by extensive deposition of extracellular matrix (ECM) proteins that produce a fibrous scar in the injure...
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Tatiana Kisseleva,
David A. Brenner
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Review article
(In Press Corrected Proof)
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14 December 2011 |
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Prediction of response to pegylated interferon plus ribavirin in HIV/hepatitis C virus (HCV)-coinfected patients using HCV genotype, IL28B variations, and HCV-RNA load
DOI: 10.1016/j.jhep.2011.11.008
Background & Aims: This study aimed at developing a predictive algorithm based on interleukin 28B (IL28B) genotype, hepatitis C virus (HCV) genotype, and plasma HCV-RNA load, which could accuratel...
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Karin Neukam,
Angela Camacho,
Antonio Caruz,
Norma Rallón,
Almudena Torres-Cornejo,
Jürgen K. Rockstroh,
Juan Macías,
Antonio Rivero,
José M. Benito,
Luis F. López-Cortés,
Jacob Nattermann,
Jesús Gómez-Mateos,
Vicente Soriano,
Juan A. Pineda
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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Whole genome RNA expression profiling of endoscopic biliary brushings provides data suitable for biomarker discovery in cholangiocarcinoma
DOI: 10.1016/j.jhep.2011.10.022
Background & Aims: Molecular analyses of biliary brushings using microarray and qPCR have the potential to provide valuable information on the biology of biliary diseases. Microarray analysis of b...
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Michael H. Chapman,
Robert Tidswell,
James S. Dooley,
Neomal S. Sandanayake,
Virginie Cerec,
Maesha Deheragoda,
Alvin J.X. Lee,
Charles Swanton,
Fausto Andreola,
Stephen P. Pereira
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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Diagnosis of liver fibrosis and cirrhosis using liver stiffness measurement: Comparison between M and XL probe of FibroScan®
DOI: 10.1016/j.jhep.2011.10.017
Background & Aims: Unreliable results of liver stiffness measurement are obtained in 16% of cases and are independently associated with body mass index (BMI) greater than 30kg/m2. A new FibroScan®...
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Victor de Lédinghen,
Vincent Wai-Sun Wong,
Julien Vergniol,
Grace Lai-Hung Wong,
Juliette Foucher,
Shirley Ho-Ting Chu,
Brigitte Le Bail,
Paul Cheung-Lung Choi,
Faiza Chermak,
Karen Kar-Lum Yiu,
Wassil Merrouche,
Henry Lik-Yuen Chan
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets
DOI: 10.1016/j.jhep.2011.10.018
Background & Aims: The dramatic rise of nonalcoholic fatty liver disease (NAFLD) among children in the past decade cannot be solely explained by the increased high fat diet (HFD) intake in kids. R...
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Jiong Li,
Jin Huang,
Jian-Shuang Li,
Hong Chen,
Kun Huang,
Ling Zheng
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients
DOI: 10.1016/j.jhep.2011.10.019
Background & Aims: CXCL1 is a ligand for CXC chemokine-receptor 2 expressed on hepatic stellate cells (HSC). Thus, CXCL1 might contribute to HSC activation and fibrogenesis. Here, we investigated ...
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Hans Dieter Nischalke,
Cordula Berger,
Carolin Luda,
Tobias Müller,
Thomas Berg,
Martin Coenen,
Benjamin Krämer,
Christian Körner,
Jonel Trebicka,
Frank Grünhage,
Frank Lammert,
Jacob Nattermann,
Tilman Sauerbruch,
Ulrich Spengler
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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Risk factors for resistance to ceftriaxone and its impact on mortality in community, healthcare and nosocomial spontaneous bacterial peritonitis
DOI: 10.1016/j.jhep.2011.11.010
Background & Aims: The recent emergence of third-generation cephalosporin resistance in spontaneous bacterial peritonitis is of great concern, although neither the risk factors for resistance nor ...
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Xavier Ariza,
José Castellote,
Jaime Lora-Tamayo,
Anna Girbau,
Sílvia Salord,
Rosa Rota,
Javier Ariza,
Xavier Xiol
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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The interaction of hepatic lipid and glucose metabolism in liver diseases
DOI: 10.1016/j.jhep.2011.08.025
Summary: It is widely known that the liver is a central organ in lipogenesis, gluconeogenesis and cholesterol metabolism. However, over the last decades, a variety of pathological conditions highlight...
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Lars P. Bechmann,
Rebekka A. Hannivoort,
Guido Gerken,
Gökhan S. Hotamisligil,
Michael Trauner,
Ali Canbay
et al.
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Review article
(In Press Corrected Proof)
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14 December 2011 |
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T cell responses and viral variability in blood donation candidates with occult hepatitis B infection
DOI: 10.1016/j.jhep.2011.11.011
Background & Aims: Occult HBV infection (OBI) is defined by the presence of HBV DNA in the liver and/or serum and negative HBsAg testing. Since the implementation of highly sensitive HBV DNA scree...
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Marta Bes,
Victor Vargas,
Maria Piron,
Natalia Casamitjana,
Juan Ignacio Esteban,
Nuria Vilanova,
Asuncion Pinacho,
Josep Quer,
Lluis Puig,
Jaime Guardia,
Silvia Sauleda
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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Quantitative dynamics of hepatitis B basal core promoter and precore mutants before and after HBeAg seroconversion
DOI: 10.1016/j.jhep.2011.11.012
Background & Aims: Hepatitis B e antigen (HBeAg) seroconversion is an important clinical and virological “landmark” during chronic hepatitis B virus (HBV) infection. Mutant viruses carrying the pr...
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Hui Nie,
Alison A. Evans,
W. Thomas London,
Timothy M. Block,
Xiangdong David Ren
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice
DOI: 10.1016/j.jhep.2011.11.013
Background & Aims: Liver fibrosis is associated with angiogenesis and leads to portal hypertension. Certain antibiotics reduce complications of liver failure in humans, however, the effects of ant...
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Qiang Zhu,
Li Zou,
Kumaravelu Jagavelu,
Douglas A. Simonetto,
Robert C. Huebert,
Zhi-Dong Jiang,
Herbert L. DuPont,
Vijay H. Shah
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |
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Insulin resistance is associated with a higher risk of hepatocellular carcinoma in cirrhotic HIV/HCV-co-infected patients: Results from ANRS CO13 HEPAVIH
DOI: 10.1016/j.jhep.2011.11.009
Background & Aims: Compared to HCV-mono-infected patients, hepatocellular carcinoma (HCC) occurs at younger age in HIV/HCV-co-infected patients, is markedly more advanced at diagnosis, is less ame...
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Dominique Salmon,
Firouzé Bani-Sadr,
Marc-Arthur Loko,
Hind Stitou,
Anne Gervais,
Jacques Durant,
Eric Rosenthal,
Yann Quertainmont,
Karl Barange,
Daniel Vittecoq,
Michka Shoai-Tehrani,
Muriel Alvarez,
Maria Winnock,
Jean Claude Trinchet,
François Dabis,
Philippe Sogni
et al.
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Full-length article
(In Press Corrected Proof)
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14 December 2011 |