Intramuscular transplantation of engineered hepatic tissue constructs corrects acute and chronic liver failure in mice

Navarro-Alvarez, Nalu; Soto-Gutierrez, Alejandro; Chen, Yong; Caballero-Corbalan, Jose; Hassan, Wael; Kobayashi, Satoru; Kondo, Yoshitaka; Iwamuro, Masaya; Yamamoto, Kazuhide; Kondo, Eisaku; Tanaka, Noriaki; Fox, Ira J.; Kobayashi, Naoya

doi:10.1016/j.jhep.2009.11.019

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Volume 52, Issue 2 , Pages 211-219, February 2010

Intramuscular transplantation of engineered hepatic tissue constructs corrects acute and chronic liver failure in mice

Nalu Navarro-Alvarez
- Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
- Present address: Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical, Boston, MA 02129, USA.
Alejandro Soto-Gutierrez
- Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
- Present address: Department of Surgery, Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, MA 02114, USA.
Yong Chen
- Marion Bessin Liver Research Center, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Ullmann 523, Bronx, NY 10461, USA
Jose Caballero-Corbalan
- Departments of Oncology, Radiology & Clinical Immunology, Division of Clinical Immunology, The Rudbeck Laboratory, Uppsala University, Uppsala SE-751 85, Sweden
Wael Hassan
- Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Satoru Kobayashi
- 3-D Matrix Japan, Ltd., 3-2-4 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan
Yoshitaka Kondo
- Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Masaya Iwamuro
- Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Kazuhide Yamamoto
- Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Eisaku Kondo
- Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Noriaki Tanaka
- Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Ira J. Fox
- Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Naoya Kobayashi
- Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
- Corresponding author. Address: Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. Tel./fax: +81 86 235 7485.

Received 1 February 2009; received in revised form 16 July 2009; accepted 20 July 2009. published online 08 December 2009.

See Editorial, pages 150–152

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PII: S0168-8278(09)00795-8

doi:10.1016/j.jhep.2009.11.019

Refers to article:

Will nano-fibers permit to turn liver cell transplantation into a curative tool against liver failure? , 09 November 2009
Nicolas Moniaux, Jamila Faivre
Journal of Hepatology February 2010 (Vol. 52, Issue 2, Pages 150-152)
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