What offers the best prediction of sustained virologic response during combination therapy with interferon and ribavirin: Viral dynamics, viral levels at certain time points, or a combination of both?☆
Abbreviations: HCV, hepatitis C virus, PEG-IFN, pegylated interferon, RBV, ribavirin, CHC, chronic hepatitis C, SVR, sustained virologic response, NPV, negative predictive value, PPV, high positive predictive value, VD, viral decline, VL, viral load
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☆ The author has declared that he has received grants from Schering-Plough, Roche, Tibotec and Swedish Orphans and has declared that that he has been on the Speakers Bureau for Schering-Plough, Roche, Tibotec, Swedish Orphans, Bristol Myers Squibb, Gilead and Novartis. He also declared that he is the P.I. in Sweden for studies run by Roche, Schering-Plough, Merch Sharp; Dome Limited and Swedish Orphans.
PII: S0168-8278(09)00240-2
doi:10.1016/j.jhep.2009.04.002
© 2009 European Association for the Study of the Liver. Published by Elsevier Inc. All rights reserved.
Refers to article:
- Positive and negative prediction of sustained virologic response at weeks 2 and 4 of treatment with albinterferon alfa-2b or peginterferon alfa-2a in treatment-naïve patients with genotype 1, chronic hepatitis C , 12 March 2009
