Journal of Hepatology
Volume 47, Issue 2 , Pages 245-252, August 2007

Hyperammonemia acts synergistically with lipopolysaccharide in inducing changes in cerebral hemodynamics in rats anaesthetised with pentobarbital

  • Hans R. Pedersen

      Affiliations

    • Department of Hepatology, Rigshospitalet, Section A-2121, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
    • Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Science, University of Copenhagen, Denmark
  • ,
  • Helmer Ring-Larsen

      Affiliations

    • Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Science, University of Copenhagen, Denmark
  • ,
  • Niels Vidiendal Olsen

      Affiliations

    • Department of Neuroanesthesia, Rigshospitalet, Copenhagen University Hospital, Denmark
  • ,
  • Fin Stolze Larsen

      Affiliations

    • Department of Hepatology, Rigshospitalet, Section A-2121, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
    • Corresponding Author InformationCorresponding author. Tel.: +45 35452155; fax: +45 35452913.

Received 29 June 2006; received in revised form 12 March 2007; accepted 27 March 2007. published online 21 April 2007.

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 The authors who have taken part in this study declared that they have no relationship with the manufacturers of the drugs involved either in the past or present and did not receive funding from the manufacturers to carry out their research. They received funding from the NOVO Nordic Foundation, Savværksejer Jeppe & Ovita Juhl’s Mindelegat, Fabricant Vilhelm Pedersen & Wifes Mindelegat, A.P. Moller Scientific Foundation, The Danish Hospital Foundation for Medical Research-Region of Copenhagen, the Faroe Islands & Greenland, The Danish Medical Association Research Fund and the Laerdal Foundation for acute Medicine, which enabled them to carry out their study.

PII: S0168-8278(07)00213-9

doi:10.1016/j.jhep.2007.03.026

Journal of Hepatology
Volume 47, Issue 2 , Pages 245-252, August 2007